《药物合成反应》人名反应

《药物合成反应》人名反应

授课教师：武汉大学药学院郭鹏教授

1. Aldol condensation

2010,12,20

2. Arndt–Eistert homologation

3. Baeyer–Villiger oxidation

4. Beckmann rearrangement

5. Benzilic acid rearrangement

6. Benzoin condensation

7. Birch reduction

8. Buchwald–Hartwig amination

9. Cannizzaro reaction

10. Claisen condensation

11. Claisen rearrangement

12. para-Claisen rearrangement

13. Clemmensen reduction

14. Cope rearrangement

15. Criegee mechanism of ozonolysis

16. Curtius rearrangement

17. Darzens condensation

18. Del é pine amine synthesis

19. Demjanov rearrangement

20. Tiffeneau–Demjanov rearrangement

21. Dieckmann condensation

22. Favorskii rearrangement

23. Fries rearrangement

24. Gabriel synthesis

25. Gattermann–Koch reaction

26. Hofmann rearrangement

27. Houben-Hoesch reaction

28. Jones oxidation

29. Knoevenagel condensation

30. Leuckart–Wallach reaction

31. Mannich reaction

32. Meerwein –Ponndorf–Verley reduction

33. Michael addition

34. Moffatt oxidation

35. Nef reaction

36. Oppenauer oxidation

37. Paal–Knorr furan synthesis

38. Paal–Knorr pyrrole synthesis

39. Perkin reaction

40. Pinacol rearrangement

基团迁移顺序：富电子基团迁移最快

烷基： 3o > 环己基 > 2 o > 苄基 > 1 o >甲基 >H > 苯基

取代芳基：给电子取代的迁移能力大于无取代的芳基，无取代大于吸电子基团取代的芳基 41. Pr é vost trans-dihydroxylation

42. Prins reaction

43. Reformatsky reaction

44. Reimer–Tiemann reaction

45. Robinson annulations

46. Robinson-Sch?pf reaction

47. Rosenmund reduction

48. Sandmeyer reaction

49. Schmidt rearrangement

50. Sommelet reaction

51. Sommelet–Hauser rearrangement

52. Stobbe condensation

53. Strecker amino acid synthesis

54. Swern oxidation

55. Vilsmeier-Haack reaction

56. [1,2]-Wittig rearrangement

57. [2,3]-Wittig rearrangement

58. Wolff rearrangement

59. Wolff–Kishner reduction

60. Woodward cis-dihydroxylation

有关 Cr 的氧化剂

极性反转