(HET) ARYL-p-QUINONE DERIVATIVES FOR TREATMENT OF

专利名称：(HET) ARYL-p-QUINONE DERIVATIVES FOR

TREATMENT OF MITOCHONDRIAL DISEASES

发明人：HINMAN, ANDREW, W.,WESSON, KIERON, E.申请号：EP09700856申请日：20090106公开号：EP2237664A4公开日：20130522

摘要：Methods of treating or suppressing mitochondrial diseases, such as Friedreich'sataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy,encephalopathy, lactacidosis, stroke (MELAS), Kearns-Sayre Syndrome (KSS), aredisclosed, as well as compounds useful in the methods of the invention, such as 2-(3-hydroxy-3-methyl-butyl)-6-(het)aryl-p-quinone or as 2-(3-hydroxy-3-methylbutyl)-3-(het)aryl-p-quinone derivatives. Energy biomarkers useful in assessing the metabolicstate of a subject and the efficacy of treatment are also disclosed. Methods of

modulating, normalizing, or enhancing energy biomarkers, as well as compounds usefulfor such methods, are also disclosed.

申请人：EDISON PHARMACEUTICALS, INC.

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