Product Name:CAS No.: Cat. No.:MWt:Formula:Purity :
iCRT 14677331-12-3HY-16665375.44C21H17N3O2S>98%
Solubility:DMSO > 50 mg/ml
Mechanisms:
Pathways:Wnt/Hedgehog/Notch; Target:Wnt
Biological Activity:
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays ofWnt pathway activity). IC50 value: 40.3 nM [1] Target: Wnt inhibitor
Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cyclearrest in HCT-116 and HT29 cell lines.
References:
[1]. Gonsalves FC, et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors ofthe Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5954-63.
[2]. Watanabe K, et al. Winning WNT: race to Wnt signaling inhibitors. Proc Natl Acad Sci U S A. 2011 Apr12;108(15):5929-30.
Caution: Not fully tested. For research purposes only
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